I have many projects I am working on or thinking about simultaneously. I do try to focus on the ones I'm actually playing or have a good chance of playing in the near future, but sometimes I work on other things. For instance I'd like to play a campaign in the Warcraft Universe, where the Warcraft series of games including the RTS Warcraft III and the MMORPG World of Warcraft are set. So I have been working on a map of Kalimdor, one of the continents in the series.
This map is large scale, with 30 mile hexes. Thus I am using twelve sheets of hex graph paper. One of the things I have noticed is that since the MMO has regions that should logically be much smaller in relation to the continent as they are presented as being, I have had to make decisions as to where these should be in relation to one another. For instance the zone called "the Thousand Needles" is supposed to be close to several zones, which are thousands of miles apart on my map. I had to make a decision as to where I wanted to put it, near on of the three zones, or somewhere in the middle. Ultimately I decided to put it near Feralas, a zone of jungle, as the explanation of it's existence presented in one of the RPG books that made the most sense to me, required it to be near that zone.
Ultimately, the fact that there is a lot of space between established regions is actually a bit of a blessing. There is a lot of space to put stuff that might not fit in one of the other regions. Furthermore players of the games will not know everything there is to know about Kalimdor. There will still be a lot of secrets. Though for some of the larger regions they still won't know everything. So over all I'm feeling good about my efforts. Just a few kinks to work out.